Targeting PAK etk…

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Kirk Pak

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Tightly-Secure PAK(E)

We present a security reduction for the PAK protocol instantiated over Gap Diffie-Hellman Groups that is tighter than previously known reductions. We discuss the implications of our results for concrete security. Our proof is the first to show that the PAK protocol can provide meaningful security guarantees for values of the parameters typical in today’s world.

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PAK signaling in cancer

Transformation of a normal cell to a cancer cell is caused by mutations in genes that regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and Cdc42 orchestrate many of the signals that are required for malignant transformation. The p21-activated kinases (PAKs) are effectors of Rac and Cdc42. PAKs are a family of serine/threonine protein kinases comprised of six ...

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The genetics of Pak.

p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. With the notable exception of plants, nearly all eukaryotes encode one or more Pak genes, indicating an ancient origin and important function for this family of enzymes. Genetic approaches in many different experimental systems, ranging from yeast ...

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PAK family kinases

The p21-activated kinases (PAKs) are a family of Ser/Thr protein kinases that are represented by six genes in humans (PAK 1-6), and are found in all eukaryotes sequenced to date. Genetic and knockdown experiments in frogs, fish and mice indicate group I PAKs are widely expressed, required for multiple tissue development, and particularly important for immune and nervous system function in the a...

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ژورنال

عنوان ژورنال: Cancer Biology & Therapy

سال: 2004

ISSN: 1538-4047,1555-8576

DOI: 10.4161/cbt.3.1.691